This hypothesis paper is a huge leap forward and will hopefully cultivate a new direction for the treatment of dysbiosis and gut disorders. They list several factors, but the one of particular interest is the absence of periods where our microbes dysbiosis sibo from the food we eat to the dysbiosis sibo we secrete.
In other words, a constant orgy of high calorie foods is an environment that our gut just isn't prepared for. A quote: "We here propose that overfeeding of the host-associated bacterial community, particularly with easily digestible, energy-dense, low-fiber-content foods, likely causes dysbiosis and the development of disease. Overfeeding uncouples natural host-microbe associations, leading to an increased activity and changed functionality of the associated microbiota.
This may lead to a changed composition and increase of bacterial by-products in the gut. Taken together, the reduction of the mucus barrier function and the increased release of bacterial by-products into the gut elevate nonself recognition of the host and stimulate the immune system.
Additional nonself recognition and stimulation of the immune system anywhere in the body likely initiate an immune response, which might contribute to the development of complex disease, such as atopic dermatitis, asthma, or diabetes.
Now all we need is for the focus to spread beyond just food and encompass circadian rhythms, physical activity, sleep, stress, social interaction, and everything else that matters! Giardia endoszkópia Exposure of the Host-Associated Microbiome to Nutrient-Rich Conditions May Lead to Dysbiosis and Disease Development—an Evolutionary Perspective Inflammatory diseases, such as inflammatory bowel diseases, are dramatically increasing worldwide, but an understanding of the underlying factors is lacking.
We here present an ecoevolutionary perspective on the emergence of inflammatory diseases. We propose that adaptation has led to fine-tuned hos